Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging

  • Mol Biosyst. 2013 Apr 5;9(4):630-3. doi: 10.1039/c3mb70022d.
Hang-Suk Chun  1 ,  Jong Hyun Jeon ,  Haushabhau S Pagire ,  Jae Hong Lee ,  Hee-Chung Chung ,  Myoung Joo Park ,  Ju-Hoon So ,  Jae-Ho Ryu ,  Cheol-Hee Kim ,  Jin Hee Ahn ,  Myung Ae Bae
Affiliations
  • 1. Bioorganic Science Division, Korea Research Institute of Chemical Technology, Jang-Dong 100, Yuseong, Daejeon, 305-600, South Korea.
PMID: 23412429 DOI: 10.1039/c3mb70022d
Abstract

We have developed LipidGreen2, a second generation small molecule probe for lipid imaging. LipidGreen2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish. We also demonstrate the application of LipidGreen2 for detecting fatty liver.

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