Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis

  • Nat Prod Res. 2013;27(18):1695-9. doi: 10.1080/14786419.2013.768988.
Anne Dayse Soares da Silva  1 ,  Luiz Henrique Agra Cavalcante-Silva ,  Carolina B Brito da Matta ,  Diego de Farias Silva ,  Morgana Vital de Araújo ,  Josean F Tavares ,  Marcelo S da Silva ,  Magna Suzana Alexandre-Moreira
Affiliations
  • 1. a Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa , Paraíba , Brazil.
PMID: 23425114 DOI: 10.1080/14786419.2013.768988
Abstract

In this study, we investigated the antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID₅₀ = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the Other hand, 7MF did not increase the latency time of the Animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity.

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