Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla

  • J Nat Prod. 2013 Apr 26;76(4):723-6. doi: 10.1021/np3006937.
Sarot Cheenpracha  1 ,  Thunwadee Ritthiwigrom ,  Surat Laphookhieo
Affiliations
  • 1. School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand. [email protected]
PMID: 23806072 DOI: 10.1021/np3006937
Abstract

Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known Alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.