Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana

  • J Nat Prod. 1990 Mar-Apr;53(2):382-90. doi: 10.1021/np50068a017.
G R Pettit  1 ,  D L Herald ,  G M Cragg ,  J A Rideout ,  P Brown
Affiliations
  • 1. Cancer Research Institute, Arizona State University, Tempe 85287.
PMID: 2380713 DOI: 10.1021/np50068a017
Abstract

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 micrograms/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.

Products