Quinaldopeptin, a novel antibiotic of the quinomycin family

  • J Antibiot (Tokyo). 1990 Jul;43(7):796-808. doi: 10.7164/antibiotics.43.796.
S Toda  1 ,  K Sugawara ,  Y Nishiyama ,  M Ohbayashi ,  N Ohkusa ,  H Yamamoto ,  M Konishi ,  T Oki
Affiliations
  • 1. Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
PMID: 2387774 DOI: 10.7164/antibiotics.43.796
Abstract

Quinaldopeptin, a new type of quinomycin Antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The Antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known Antibiotics of the quinomycin family by the lack of ester linkage.

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