Cytotoxic lignans from Viburnum foetidum

  • Arch Pharm Res. 2013 Oct;36(10):1211-4. doi: 10.1007/s12272-013-0218-z.
Hong Li  1 ,  Yuanguo Luo ,  Yan Ma ,  Jun Zeng ,  Xu Zhang ,  Dong Wang ,  Chunlin Hu
Affiliations
  • 1. Department of Anesthesiology, No. 181 Hospital of PLA, Guilin, 541002, GuangXi Province, People's Republic of China.
PMID: 23881703 DOI: 10.1007/s12272-013-0218-z
Abstract

Two new Lignans, 3,4,4'-trihydroxy-3',9-dimethoxy-9,9'-epoxylignan (1), 3,4'-dihydroxy-3',4, 9-trimethoxy-9,9'-epoxylignan (2), together with one known compound, 4,4'-dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan (3), were isolated from the 95 % EtOH extract of Viburnum foetidum. The structures of the two new compounds were elucidated on the basis of 1D, 2D-NMR, and mass spectral analysis. All the Lignans were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).

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