An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for imaging copper(II) ions

  • Chem Commun (Camb). 2013 Dec 14;49(96):11263-5. doi: 10.1039/c3cc46585c.
Xiaobo Wang  1 ,  Xiaoyan Ma ,  Zhen Yang ,  Zhong Zhang ,  Jinghan Wen ,  Zhirong Geng ,  Zhilin Wang
Affiliations
  • 1. State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. [email protected] [email protected].
PMID: 24153319 DOI: 10.1039/c3cc46585c
Abstract

An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for detecting Cu(2+) was synthesized and used for fluorescence imaging in HeLa cells. The probe was specifically localized in lysosomes and successfully applied to visualize Cu(2+) as well as to monitor Cu(2+) level changes in the lysosomes of living cells.

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