A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

  • Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e.
Mi-Kyung Lee  1 ,  Angel Bottini ,  Meehyein Kim ,  Michael F Bardaro Jr ,  Ziming Zhang ,  Maurizio Pellecchia ,  Byong-Seok Choi ,  Gabriele Varani
Affiliations
  • 1. Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA. [email protected].
PMID: 24247110 DOI: 10.1039/c3cc46973e
Abstract

Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits Antiviral activity against influenza viruses.

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