Synthesis, characterization, cytotoxicity and antibacterial activity of an anthracenyl-linked bis(pyrazolyl)methane ligand and its zinc(II) complexes

  • Eur J Med Chem. 2014 Jan 24:72:46-51. doi: 10.1016/j.ejmech.2013.10.064.
Ban-Feng Ruan  1 ,  Ying-Zhong Zhu  2 ,  Wan-Ding Liu  2 ,  Bao-An Song  3 ,  Yu-Peng Tian  4
Affiliations
  • 1. School of Medical Engineering, Hefei University of Technology, Hefei 230009, PR China.
  • 2. Department of Chemistry, Anhui Province Key Laboratory of Functional Inorganic Material Chemistry, Anhui University, Hefei 230039, PR China.
  • 3. Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China. Electronic address: [email protected].
  • 4. Department of Chemistry, Anhui Province Key Laboratory of Functional Inorganic Material Chemistry, Anhui University, Hefei 230039, PR China. Electronic address: [email protected].
PMID: 24342667 DOI: 10.1016/j.ejmech.2013.10.064
Abstract

Three novel Zn(II) complexes (1-3) with 1,1'-(anthracen-9-ylmethylene)bis(1H-pyrazole) (L(2)) have been prepared and structurally characterized by X-ray crystallography. Among them, 1 is a binuclear Zn(II) complex while 2 and 3 are mononuclear. The in vitro cytotoxic and Antibacterial activities of these complexes were also evaluated. The three complexes exhibit cytotoxic specificity and significant antitumor activity. The MIC50 value of complex 1 against Pseudomonas putida reaching 0.011 μg/mL much lower than that the positive control chloromycin (0.182 μg/mL), indicates that complex 1 is a potent Antibacterial agent.

Keywords
1,1′-(Anthracen-9-ylmethylene)bis(1H-pyrazole); Antibacterial activity; Crystal structure; Cytotoxicity; Zinc(II) complex.