Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii

  • J Nat Prod. 2014 Jan 24;77(1):164-7. doi: 10.1021/np4007487.
Gang Ding  1 ,  Hailou Wang ,  Li Li ,  Bo Song ,  Hong Chen ,  Hongwu Zhang ,  Xinzhong Liu ,  Zhongmei Zou
Affiliations
  • 1. Institute of Medicinal Plant Development , Beijing, People's Republic of China.
PMID: 24422592 DOI: 10.1021/np4007487
Abstract

Trichodermone (1), the first spiro-cytochalasan with an unprecedented tetracyclic nucleus (7/5/6/5), together with its possible biosynthetic precursor aspochalasin D (2), was isolated from the endophytic fungus Trichoderma gamsii. Compound 2 displayed moderate inhibitory activity against HeLa cells with an IC50 value of 5.72 μM.