Withanolides from Physalis hispida

  • J Nat Prod. 2014 Mar 28;77(3):631-9. doi: 10.1021/np400953n.
Cong-Mei Cao  1 ,  Huaping Zhang ,  Robert J Gallagher ,  Victor W Day ,  Kelly Kindscher ,  Patrick Grogan ,  Mark S Cohen ,  Barbara N Timmermann
Affiliations
  • 1. Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.
PMID: 24456028 DOI: 10.1021/np400953n
Abstract

Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides with nonaromatic six-membered ring D moieties. In addition, withanolide 8 represents a novel withanolide skeleton due to the absence of a C-13-C-17 bond within the steroidal nucleus.

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