The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq

  • Biomed Res Int. 2014;2014:903529. doi: 10.1155/2014/903529.
R Mogana  1 ,  A Adhikari  2 ,  S Debnath  3 ,  S Hazra  3 ,  B Hazra  3 ,  K Teng-Jin  1 ,  C Wiart  1
Affiliations
  • 1. School of Pharmacy, Faculty of Science, Center for Natural and Medicinal Products Research, University of Nottingham (Malaysia Campus), Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
  • 2. HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan.
  • 3. Department of Pharmaceutical Technology, Jadavpur University Calcutta, West Bengal 700032, India.
PMID: 24949478 DOI: 10.1155/2014/903529
Abstract

In continuation of our natural and medicinal research programme on tropical rainforest Plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6). All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC50 29.53 ± 0.19 μ g/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50 163.30 ± 0.32 μ g/mL). Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.

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