Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species

  • Org Lett. 2014 Oct 17;16(20):5366-9. doi: 10.1021/ol502572g.
Wen Bo Han  1 ,  Yan Hua Lu ,  Ai Hua Zhang ,  Gao Fei Zhang ,  Ya Ning Mei ,  Nan Jiang ,  Xinxiang Lei ,  Yong Chun Song ,  Seik Weng Ng ,  Ren Xiang Tan
Affiliations
  • 1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
PMID: 25286294 DOI: 10.1021/ol502572g
Abstract

The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively Antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.

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