Bioactive compounds from the insect Aspongopus chinensis

  • Bioorg Med Chem Lett. 2014 Nov 15;24(22):5164-9. doi: 10.1016/j.bmcl.2014.09.083.
Yan-Ni Shi  1 ,  Zheng-Chao Tu  2 ,  Xin-Long Wang  3 ,  Yong-Ming Yan  1 ,  Ping Fang  3 ,  Zhi-Li Zuo  3 ,  Bo Hou  3 ,  Tong-Hua Yang  4 ,  Yong-Xian Cheng  5
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, People's Republic of China.
  • 2. Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, People's Republic of China.
  • 3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • 4. Department of Hematology, First People's Hospital of Yunnan Province, Kunming 650032, People's Republic of China. Electronic address: [email protected].
  • 5. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: [email protected].
PMID: 25442305 DOI: 10.1016/j.bmcl.2014.09.083
Abstract

Recent studies focusing on unveiling the biological agents of Aspongopus chinensis have led to the identification of four new norepinephrine derivatives (1-4), three new sesquiterpenoids (5-7), and one new lactam (8). In addition, twenty-three known compounds have been identified, most of which were isolated from this insect for the first time. Selected members of insect-derived substances were evaluated for their biological activities against renal protection in high-glucose-induced mesangial cells and COX-2 inhibition.

Keywords
Aspongopus chinensis; Biological evaluation; Insects; Lactam; Norepinephrine derivatives; Sesquiterpenoids.
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