Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi

  • Evid Based Complement Alternat Med. 2014:2014:506273. doi: 10.1155/2014/506273.
Ana Carolina Alves de Paula E Silva  1 ,  Caroline Barcelos Costa-Orlandi  1 ,  Fernanda Patrícia Gullo  1 ,  Fernanda Sangalli-Leite  1 ,  Haroldo Cesar de Oliveira  1 ,  Julhiany de Fátima da Silva  1 ,  Liliana Scorzoni  1 ,  Nayla de Souza Pitangui  1 ,  Suélen Andrea Rossi  1 ,  Tatiane Benaducci  1 ,  Vanessa Gonçalves Wolf  1 ,  Luis Octávio Regasini  2 ,  Maicon Segalla Petrônio  2 ,  Dulce Helena Siqueira Silva  2 ,  Vanderlan S Bolzani  2 ,  Ana Marisa Fusco-Almeida  1 ,  Maria José Soares Mendes-Giannini  1
Affiliations
  • 1. Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rodovia Araraquara-Jaú, km 1, 14 800 901 Araraquara, SP, Brazil.
  • 2. Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rua Professor Francisco Degni, 55, Bairro Quitandinha, 14800-060 Araraquara, SP, Brazil.
PMID: 25505923 DOI: 10.1155/2014/506273
Abstract

This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the Antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum Antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.

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