Sesquiterpenoid tropolone glycosides from Liriosma ovata

  • J Nat Prod. 2015 Feb 27;78(2):315-9. doi: 10.1021/np5006696.
Jun Ma  1 ,  Rahul S Pawar ,  Erich Grundel ,  Eugene P Mazzola ,  Clark D Ridge ,  Takashi Masaoka ,  Stuart F J Le Grice ,  Jennifer Wilson ,  John A Beutler ,  Alexander J Krynitsky
Affiliations
  • 1. Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States.
PMID: 25587934 DOI: 10.1021/np5006696
Abstract

Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography-quadrupole-orbital ion trap mass spectrometric (UHPLC-Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.