Diterpene alkaloids with an aza-ent-kaurane skeleton from Isodon rubescens

  • J Nat Prod. 2015 Feb 27;78(2):196-201. doi: 10.1021/np5006136.
Xu Liu  1 ,  Jing Yang ,  Wei-Guang Wang ,  Yan Li ,  Ji-Zhou Wu ,  Jian-Xin Pu ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
PMID: 25590529 DOI: 10.1021/np5006136
Abstract

Two compounds belonging to a new group of diterpene Alkaloids, kaurines A and B (1 and 2), and an alkaloid bearing a succinimide moiety (3) were obtained from Isodon rubescens. Their structures and absolute configurations were determined by spectroscopy and quantum-chemical computational (13)C NMR and ECD data analysis. These Alkaloids differ from known diterpene Alkaloids and Diterpenoids and are presumably biosynthesized from ent-kaurane Diterpenoids.