Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis

  • J Nat Prod. 2015 May 22;78(5):1179-83. doi: 10.1021/acs.jnatprod.5b00092.
Ryo Nakabayashi  1 ,  Zhigang Yang  1 ,  Tomoko Nishizawa  1 ,  Tetsuya Mori  1 ,  Kazuki Saito  1  2
Affiliations
  • 1. †RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
  • 2. ‡Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
PMID: 25922884 DOI: 10.1021/acs.jnatprod.5b00092
Abstract

The discovery of bioactive natural compounds containing sulfur, which is crucial for inhibitory activity against angiotensin-converting enzyme (ACE), is a challenging task in metabolomics. Herein, a new S-containing metabolite, asparaptine (1), was discovered in the spears of Asparagus officinalis by targeted metabolomics using mass spectrometry for S-containing metabolites. The contribution ratio (2.2%) to the IC50 value in the crude extract showed that asparaptine (1) is a new ACE Inhibitor.

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