New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells

  • Bioorg Med Chem Lett. 2015 Sep 15;25(18):3864-6. doi: 10.1016/j.bmcl.2015.07.055.
Lu Sun  1 ,  Yu-Ming Liu  2 ,  Bao-Quan Chen  1 ,  Qing-Hua Liu  3
Affiliations
  • 1. Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
  • 2. Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address: [email protected].
  • 3. Xinjiang Institute of Materia Medica, Ürümuqi 830001, PR China.
PMID: 26227777 DOI: 10.1016/j.bmcl.2015.07.055
Abstract

Four phenolic compounds, including two new ones, Nigephenol A and B (1-2), and a new natural product, Nigephenol C (3), were isolated from the seeds of Nigella glandulifera. Their structures were elucidated on the basis of spectroscopic analyses using HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated by MTT method for in vitro cytotoxicity against four human Cancer cell lines (Bel7402, HepG2, HCT-8 and A549). The results revealed that Compounds 1-4 showed more selective activities against HepG2 cells, and that Compound 2 showed significant inhibitory effects against four human tumor cell lines with IC50 values comparable to those of 5-fluorouracil.

Keywords
Cytotoxic activity; Nigella; Nigella glandulifera; Phenolic compounds; Ranunculaceae.