Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation

  • Vitam Horm. 2015;99:273-91. doi: 10.1016/bs.vh.2015.06.001.
Junjun Jing  1 ,  Robert J Hinton  2 ,  Jian Q Feng  3
Affiliations
  • 1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  • 2. Department of Biomedical Sciences, Texas A&M Baylor College of Dentistry, Dallas, Texas, USA.
  • 3. Department of Biomedical Sciences, Texas A&M Baylor College of Dentistry, Dallas, Texas, USA. Electronic address: [email protected].
PMID: 26279380 DOI: 10.1016/bs.vh.2015.06.001
Abstract

The type IA bone morphogenetic protein receptor (Bmpr1a), encoded by 11 exons and spanning about 40 kb on chromosome 14 in mice and chromosome 10 in human (Derynck & Feng, 1997; Mishina, Hanks, Miura, Tallquist, & Behringer, 2002), is an essential receptor for BMP signaling. This chapter focuses on the current understanding of the role of Bmpr1a in cartilage development and endochondral ossification, including formation of the mesenchymal condensation, chondrocyte differentiation and maturation, and endochondral bone development.

Keywords
Articular cartilage; Bmpr1a; Cartilage development; Cell fate; Endochondral bone formation; Growth plate; Mandibular condylar cartilage; Temporomandibular joint.
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