Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata

  • Fitoterapia. 2015 Dec;107:44-48. doi: 10.1016/j.fitote.2015.10.004.
Yuan Gao  1 ,  Ai-Lin Yu  2 ,  Gen-Tao Li  3 ,  Ping Hai  2 ,  Yan Li  3 ,  Ji-Kai Liu  4 ,  Fei Wang  5
Affiliations
  • 1. BioBioPha Co., Ltd., Kunming 650201, People's Republic of China; Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China.
  • 2. BioBioPha Co., Ltd., Kunming 650201, People's Republic of China.
  • 3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • 4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: [email protected].
  • 5. BioBioPha Co., Ltd., Kunming 650201, People's Republic of China. Electronic address: [email protected].
PMID: 26474672 DOI: 10.1016/j.fitote.2015.10.004
Abstract

Five new hexacyclic monoterpenoid Indole Alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new Alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.

Keywords
Cytotoxicity; Monoterpenoid indole alkaloid; Rauvolfia verticillata; Rauvovertine.
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