Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase

  • Fitoterapia. 2016 Jan:108:20-5. doi: 10.1016/j.fitote.2015.11.002.
Daisuke Mikami  1 ,  Hideyuki Kurihara  2 ,  Momoka Ono  3 ,  Sang Moo Kim  4 ,  Koretaro Takahashi  3
Affiliations
  • 1. Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Kita-ku, Sapporo 001-0021, Japan.
  • 2. Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan. Electronic address: [email protected].
  • 3. Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan.
  • 4. Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon-do 210-702, Republic of Korea.
PMID: 26586619 DOI: 10.1016/j.fitote.2015.11.002
Abstract

A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L. mesenteroides G6PD.

Keywords
Alga; Bromophenol; Glucose 6-phosphate dehydrogenase; Inhibition; Polyphenol.
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