Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar

  • J Nat Prod. 2015 Dec 24;78(12):3024-30. doi: 10.1021/acs.jnatprod.5b00824.
Nwet Nwet Win  1  2 ,  Takuya Ito  1 ,  Ismail  3 ,  Takeshi Kodama  1 ,  Yi Yi Win  2 ,  Masami Tanaka  4 ,  Hla Ngwe  2 ,  Yoshinori Asakawa  4 ,  Ikuro Abe  5 ,  Hiroyuki Morita  1
Affiliations
  • 1. Institute of Natural Medicine, University of Toyama , 2630-Sugitani, Toyama 930-0194, Japan.
  • 2. Department of Chemistry, University of Yangon , Yangon 11041, Myanmar.
  • 3. Faculty of Pharmacy, Hasanuddin University , Makassar 90245, South Sulawesi, Indonesia.
  • 4. Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Yamashiro-cho, Tokushima 770-8514, Japan.
  • 5. Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
PMID: 26606140 DOI: 10.1021/acs.jnatprod.5b00824
Abstract

Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human Cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the Cancer cells used (IC50 values >10 μM).