Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats

  • Mol Nutr Food Res. 2016 May;60(5):981-91. doi: 10.1002/mnfr.201500761.
Iveta Najmanová  1 ,  Jana Pourová  1 ,  Marie Vopršalová  1 ,  Veronika Pilařová  2 ,  Vladimír Semecký  3 ,  Lucie Nováková  2 ,  Přemysl Mladěnka  1
Affiliations
  • 1. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
  • 2. Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
  • 3. Department of Biological and Medical Science, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
PMID: 26790841 DOI: 10.1002/mnfr.201500761
Abstract

There are reports of positive effects of quercetin on cardiovascular pathologies, however, mainly due to its low biovailability, the mechanism remains elusive. Here, we report that one metabolite formed by human microflora (3-(3-hydroxyphenyl)propionic acid)relaxed isolated rat aorta and decreased arterial blood pressure in rats.

Keywords
Blood pressure; Flavonoid; Metabolite; Phenolic; Quercetin; Rat; Vascular.
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