Antimicrobial and immunomodulating effects of some phenolic glycosides

Several phenolic Glycosides, i.e. acteoside, desrhamnosyl acteoside, and purpureaside A, B and C, exerted weak Antibacterial effects on Escherichia coli. Acteoside had antiplasmid effects, including F'lac plasmid elimination, and inhibited kanamycin resistance transfer in E. coli. Acteoside, desrhamnosyl acteoside and purpureaside A displayed Antiviral effect on Aujeszky virus. All of the phenolic Glycosides decreased some human leucocyte functions, including rosette formation, mitogen-induced blast transformation and phagocytic activity in vitro. The purpureaside C had significant proinflammatory action, however, other phenolic Glycosides showed neither proinflammatory nor antiinflammatory effect on carrageenin-induced inflammation in vivo.