ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum

  • J Nat Prod. 2016 Apr 22;79(4):907-13. doi: 10.1021/acs.jnatprod.5b00954.
Quírico A Castillo ,  Jorge Triana  1 ,  José L Eiroa  1 ,  Laurent Calcul  2 ,  Edwin Rivera  2  3 ,  Lukasz Wojtas  2 ,  José M Padrón  4 ,  Lise Boberieth  2 ,  Mehdi Keramane  5 ,  Ernesto Abel-Santos  6 ,  Luis A Báez ,  Evelyn A Germosén
Affiliations
  • 1. Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
  • 2. Florida Center of Excellence for Drug Discovery and Innovation (CDDI-USF), University of South Florida , Tampa, Florida 33620, United States.
  • 3. Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33612, United States.
  • 4. BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna , 38206 La Laguna, Spain.
  • 5. Biointerfaces Institute, McMaster University , Engineering Technology Building, Room 413, 1280 Main Street West, Hamilton, ON L8S 0A3, Canada.
  • 6. Department of Chemistry and Biochemistry, University of Nevada , Las Vegas, Nevada 89154, United States.
PMID: 27023255 DOI: 10.1021/acs.jnatprod.5b00954
Abstract

Six new ent-labdane Diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM.