Small molecule targeting miR-34a for cancer therapy

  • Mol Cell Oncol. 2015 Feb 24;2(1):e977160. doi: 10.4161/23723556.2014.977160.
Zhangang Xiao  1 ,  Yangchao Chen  2
Affiliations
  • 1. School of Biomedical Sciences; Faculty of Medicine; The Chinese University of Hong Kong ; Shatin, Hong Kong.
  • 2. School of Biomedical Sciences; Faculty of Medicine; The Chinese University of Hong Kong; Shatin, Hong Kong; State Key Laboratory of Digestive Disease; Institute of Digestive Disease; The Chinese University of Hong Kong; Shatin, Hong Kong; Shenzhen Research Institute; The Chinese University of Hong Kong; Shenzhen, China.
PMID: 27308410 DOI: 10.4161/23723556.2014.977160
Abstract

miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong Anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against Cancer.

Keywords
anticancer drug; hepatocellular carcinoma; miR-34a.
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