The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice

  • Int J Biol Macromol. 2016 Oct:91:1170-6. doi: 10.1016/j.ijbiomac.2016.06.083.
Mei Liu  1 ,  Yu Zhang  2 ,  Hui Zhang  3 ,  Bo Hu  4 ,  Li Wang  5 ,  Haifeng Qian  6 ,  Xiguang Qi  7
Affiliations
  • 1. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  • 2. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  • 3. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  • 4. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  • 5. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  • 6. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  • 7. State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
PMID: 27365119 DOI: 10.1016/j.ijbiomac.2016.06.083
Abstract

This study was initiated to investigate the mechanism by which OAT β-d-glucan (OBG) can control blood sugar levels and improve hepatogenic glycometabolism in streptozotocin-nicotinamide induced mice. After administration of different concentrations and molecular weights of β-d-glucan by oral gavage for 28 days, the body weight, fasting blood glucose, serum Insulin, hepatic glycogen, glucose kinase and glucose-6-phosphatase activity of the diabetic mice were measured. In comparison with a negative control group (saline), β-d-glucan, especially medium or high doses of high-molecular-weight β-d-glucan, had a strong hypoglycaemic effect in streptozotocin-nicotinamide-induced mice. The mechanism of this effect may be associated with the high viscosity of the solution, an increase in Insulin secretion, a decline in Insulin resistance, and especially an improvement in hepatogenic glycometabolism. Moreover, β-d-glucan also markedly repaired and improved the integrity of pancreatic islet β-cell and tissue structures.

Keywords
Diabetes; Hepatogenic glycometabolism; β-d-glucan.
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