Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

  • Acta Pharm Sin B. 2016 Nov;6(6):564-567. doi: 10.1016/j.apsb.2016.05.009.
Chuangfeng Zhang  1 ,  Jian Zhou  2 ,  Jingzhi Yang  1 ,  Chuangjun Li  1 ,  Jie Ma  1 ,  Dan Zhang  1 ,  Dongming Zhang  1
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
PMID: 27818923 DOI: 10.1016/j.apsb.2016.05.009
Abstract

Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells.

Keywords
Cuneataside E; Cuneataside F; Extraction and isolation; Hepatoprotective activity; Lespedeza cuneata; Phenylpropanoid glycosides.
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