A new flavonoid from Sophora flavescens Ait

  • Nat Prod Res. 2017 Oct;31(19):2228-2232. doi: 10.1080/14786419.2017.1297992.
Rong Huang  1 ,  Yi Liu  2 ,  Lin-Lin Zhao  1 ,  Xi-Xin Chen  1 ,  Feng Wang  1 ,  Wei Cai  3 ,  Lei Chen  1
Affiliations
  • 1. a Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica , Guangdong Pharmaceutical University , Guangzhou , China.
  • 2. b School of Chinese Medicine , Southern Medical University , Guangzhou , China.
  • 3. c Department of Pharmacy , Hunan University of Medicine , Huaihua , China.
PMID: 28278618 DOI: 10.1080/14786419.2017.1297992
Abstract

A new flavonoid, 8-(3-hydroxymethyl-2-butenyl)-5,7,2',4'-tetrahydroxyflavanone (1), along with seven known compounds, (2R)-3α,7,4'-Trihydroxy -5-methoxy-8-prenylflavanone (2), (2R)-3β,7,4'- Trihydroxy-5-methoxy-8-prenylflavanone (3), 3,7-dihydroxycoumarin (4), Shandougenines B (5), Specionin (6), Kushenol N (7) and Kushenol I (8) were isolated from the roots of Sophora flavescens. Among them, Compound 5 was isolated from Leguminous Plants, and compounds 4 and 6 were isolated from Sophora flavescens for the first time. Their structures were elucidated by the aid of NMR, HRMS, HMBC and CD spectroscopic methods.

Keywords
Sophora flavescens; isolation; structural identification.
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