Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43

  • Med Mycol. 2017 Nov 1;55(8):890-894. doi: 10.1093/mmy/myx013.
Thais Bernardi  1 ,  Julhiany de Fátima da Silva  1 ,  Juliana Vicentin  1 ,  Haroldo Cesar de Oliveira  1 ,  Patricia Akemi Assato  1 ,  Caroline Maria Marcos  1 ,  Ana Carolina Alves de Paula E Silva  1 ,  Rosangela Aparecida Moraes da Silva  1 ,  Luis Octávio Regasini  2 ,  Dulce Helena Siqueira Silva  3 ,  Vanderlan da Silva Bolzani  3 ,  Ana Marisa Fusco-Almeida  1 ,  Maria José Soares Mendes-Giannini  1
Affiliations
  • 1. Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Campus Araraquara, Departamento de Análises Clínicas, Laboratório de Micologia Clínica, Araraquara, São Paulo, Brasil.
  • 2. Universidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, Campus São José do Rio Preto, Departamento de Química e Ciências Ambientais, São José do Rio Preto, São Paulo, Brasil.
  • 3. Universidade Estadual Paulista (UNESP), Instituto de Química, Campus Araraquara Departamento de Química Orgânica, Araraquara, São Paulo, Brasil.
PMID: 28339963 DOI: 10.1093/mmy/myx013
Abstract

Apoptosis is considered an escape mechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of Apoptosis caused by this fungus. Decyl gallate (G14) is a known Antifungal compound, and we decided to investigate its anti-apoptotic properties. Our results demonstrate that G14 was effective against Apoptosis induced by gp43, as observed in epithelial cells, and led to a reduction in DNA damage, Bak down-regulation and Bcl-2 up-regulation. Together, these data show that G14 presents promising anti-apoptotic activity.

Keywords
Paracoccidioides brasiliensis; apoptosis; decyl gallate; gp43.
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