A new coruleoellagic acid derivative from stems of Rhodamnia dumetorum

  • Nat Prod Res. 2018 Jul;32(14):1653-1659. doi: 10.1080/14786419.2017.1395430.
Waranya Lakornwong  1 ,  Kwanjai Kanokmedhakul  1 ,  Somdej Kanokmedhakul  1
Affiliations
  • 1. a Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science , Khon Kaen University , Khon Kaen , Thailand.
PMID: 29073789 DOI: 10.1080/14786419.2017.1395430
Abstract

A new coruleoellagic acid derivative, 3,3',4,4',5'-pentamethylcoruleoellagic acid (1) together with nine known compounds, hexamethylcoruleoellagic acid (2), 3,4,3'-tri-O-methylellagic acid (3), heptaphylline (4), 7-methoxymukonal (5), dentatin (6), sinapaldehyde (7), gallic acid (8), 2,6-dimethoxy-4H-pyran-4-one (9) and β-sitosterol (10) were isolated from the stems of Rhodamnia dumetorum. Their structures were identified by physical and spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds 1, 2 and 7-10 were tested for Antibacterial activity against six pathogenic Bacterial strains (Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, and Methicillin resistant S. aureus (MRSA)).

Keywords
Rhodamnia dumetorum; antibacterial; carbazole; coruleoellagic acid; gallic acid.
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