Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora
- Bioorg Med Chem Lett. 2018 Jun 1;28(10):1860-1863. doi: 10.1016/j.bmcl.2018.04.006.
- 1. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
- 2. Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
- 3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan.
- 4. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
- 5. Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.
- 6. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: [email protected].
A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Garcinia multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1-3 were evaluated in human endothelial progenitor cells (EPCs) and Cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate Cancer cell line PC-3 with GI50 values of 4.3 ± 1.6 and 6.6 ± 0.4 μM, respectively.