Anti- Mycobacterium tuberculosis Terpenoids from Resina Commiphora

  • Molecules. 2019 Apr 15;24(8):1475. doi: 10.3390/molecules24081475.
Chuan-Zhi Zhu  1  2 ,  Bin-Yuan Hu  3 ,  Jia-Wang Liu  4 ,  Yi Cai  5 ,  Xin-Chun Chen  6 ,  Da-Peng Qin  7 ,  Yong-Xian Cheng  8 ,  Zong-De Zhang  9
Affiliations
  • 1. Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. [email protected].
  • 2. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 3. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 4. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 5. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 6. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 7. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 8. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 9. Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. [email protected].
PMID: 30991677 DOI: 10.3390/molecules24081475
Abstract

Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known Terpenoids (5-7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels-Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human Cancer cells and THP-1 monocyte cells was examined.

Keywords
Resina Commiphora; anti-Mycobacterium tuberculosis; plant resins; terpenoids.
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