Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer

  • Bioorg Med Chem Lett. 2019 Jul 15;29(14):1732-1736. doi: 10.1016/j.bmcl.2019.05.022.
Mayu Kimura  1 ,  Kanae Sasaki  2 ,  Yosuke Fukutani  1 ,  Hiderou Yoshida  2 ,  Ikuroh Ohsawa  3 ,  Masafumi Yohda  1 ,  Kaori Sakurai  4
Affiliations
  • 1. Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan.
  • 2. Department of Biochemistry and Molecular Biology, Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo 678-1297, Japan.
  • 3. Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
  • 4. Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan. Electronic address: [email protected].
PMID: 31126855 DOI: 10.1016/j.bmcl.2019.05.022
Abstract

OSW-1 is a plant-derived natural product proposed to selectively kill Cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive. Here, we discovered that OSW-1 selectively activates the Golgi stress response leading to Apoptosis, providing a mechanistic basis for the Anticancer activity of OSW-1.

Keywords
Anticancer natural product; Golgi stress response; OSBP; OSW-1; Saponin.