Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. I. Taxonomy, production, isolation, physico-chemical properties and biological activities

  • J Antibiot (Tokyo). 1988 Aug;41(8):1009-14. doi: 10.7164/antibiotics.41.1009.
T Aoyagi  1 ,  S Yoshida ,  S Harada ,  A Okuyama ,  C Nakayama ,  T Yoshida ,  M Hamada ,  T Takeuchi ,  H Umezawa
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 3139601 DOI: 10.7164/antibiotics.41.1009
Abstract

Benadrostin, a new inhibitor of poly(ADP-ribose) synthetase was discovered in the fermentation broth of Streptomyces flavovirens MH499-O'F1. It was purified by chromatography followed by solvent extraction and then isolated as colorless prisms. Benadrostin has the molecular formula of C8H5NO4. It was competitive with the substrate, and the inhibition constant (Ki) was 34 microM.

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