Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats

  • Bull Exp Biol Med. 2019 Nov;168(1):52-54. doi: 10.1007/s10517-019-04644-4.
O O Masalova  1 ,  S B Kazakova  2 ,  T N Savateeva-Lyubimova  2 ,  K V Sivak  2 ,  N S Sapronov  3 ,  P D Shabanov  3
Affiliations
  • 1. Institute of Experimental Medicine, Ministry of Health of the Russian Federation, St. Petersburg, Russia. [email protected].
  • 2. Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
  • 3. Institute of Experimental Medicine, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
PMID: 31741247 DOI: 10.1007/s10517-019-04644-4
Abstract

We studied the effect of gonadotropin-releasing hormone agonist surfagon (2 μg/kg, once, intraperitoneally) on anxious behavior of adult gonadectomized and non-gonadectomized male rats. It was shown that surfagon significantly increased anxiety of both gonadectomized and non-gonadectomized rats in the open-field test and in elevated plus maze.

Keywords
follicle-stimulating; gonadotropin-releasing hormone; hormone; testosterone; anxiety; luteinizing hormone.
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