Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

  • Molecules. 2019 Dec 26;25(1):99. doi: 10.3390/molecules25010099.
Jing-Hua Yang  1 ,  Xin-Yi Wang  2 ,  Yi-Ping Zhou  3 ,  Rong Lu  1 ,  Chin-Ho Chen  4 ,  Meng-Han Zhang  5 ,  Yung-Yi Cheng  5  6 ,  Susan L Morris-Natschke  5 ,  Kuo-Hsiung Lee  5  6 ,  Yun-Song Wang  1
Affiliations
  • 1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • 2. The High School Affiliated to Yunnan Normal University, Kunming 650106, China.
  • 3. School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
  • 4. Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • 5. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • 6. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan.
PMID: 31888067 DOI: 10.3390/molecules25010099
Abstract

Two new Carbazole Alkaloids (1,2) and six known Carbazole Alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.

Keywords
Clausena anisum-olens; Rutaceae; anti-HIV; carbazole alkaloids.
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