Natural sesquiterpenoid oligomers: A chemical perspective

  • Eur J Med Chem. 2020 Oct 1:203:112622. doi: 10.1016/j.ejmech.2020.112622.
Wen-Yu Zhao  1 ,  Juan-Juan Yan  1 ,  Tian-Tian Liu  1 ,  Jian Gao  2 ,  Hui-Lian Huang  3 ,  Cheng-Peng Sun  4 ,  Xiao-Kui Huo  1 ,  Sa Deng  1 ,  Bao-Jing Zhang  1 ,  Xiao-Chi Ma  5
Affiliations
  • 1. Institute of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.
  • 2. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.
  • 3. Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
  • 4. Institute of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China. Electronic address: [email protected].
  • 5. Institute of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China. Electronic address: [email protected].
PMID: 32688203 DOI: 10.1016/j.ejmech.2020.112622
Abstract

Sesquiterpenoid oligomers, biogenetically assembled by at least two monomeric sesquiterpenoid units via diverse pathways, represent a unique class of natural products with distinct bioactivities. Herein, we provide a review covering the dimeric, trimeric, and tetrameric sesquiterpenoids categorized by reaction types in biosynthesis from a chemical perspective. Emphasis is focused on the biosynthetic oligomerization pathways of these interesting molecules and their related biological functions, which will supply inspiration for the total synthesis or biomimetic synthesis of more oligomeric sesquiterpenoids and further pharmacological investigations.

Keywords
Bioactivities; Biomimetic synthesis; Biosynthetic pathways; Sesquiterpenoid oligomers.