Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment

  • Trends Cancer. 2021 Jun;7(6):484-487. doi: 10.1016/j.trecan.2021.01.013.
Tatiana A Mishchenko  1 ,  Irina V Balalaeva  1 ,  Maria V Vedunova  1 ,  Dmitri V Krysko  2
Affiliations
  • 1. Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation.
  • 2. Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation; Cell Death Investigation and Therapy (CDIT) Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address: [email protected].
PMID: 33640304 DOI: 10.1016/j.trecan.2021.01.013
Abstract

Photodynamic therapy (PDT) is widely used in Cancer treatment; however, several challenges compromise its efficiency. We propose a synergistic action between PDT and ferroptotic cell death. PDT acts as a source of Reactive Oxygen Species for the Fenton reaction, which may reinforce Ferroptosis induction and increase PDT efficacy in Anticancer therapy.

Keywords
cancer therapy; ferroptosis; immunogenic cell death; immunotherapy; photosensitizes.