Peptide Blocking Self-Polymerization of Extracellular Calcium-Sensing Receptor Attenuates Hypoxia-Induced Pulmonary Hypertension

  • Hypertension. 2021 Nov;78(5):1605-1616. doi: 10.1161/HYPERTENSIONAHA.120.16712.
Rui Xiao  1  2 ,  Shengquan Luo  1  2 ,  Ting Zhang  1  2 ,  Yankai Lv  2  3 ,  Tao Wang  2  4 ,  Jiwei Zhang  5 ,  Yuan Su  2  6 ,  Matthieu Ruiz  7  8 ,  Jocelyn Dupuis  8  9 ,  Liping Zhu   #  1  2 ,  Qinghua Hu   #  1  2
Affiliations
  • 1. From the Department of Pathophysiology, School of Basic Medicine (R.X., S.L., T.Z., L.Z., Q.H.).
  • 2. Key Laboratory of Pulmonary Diseases of Ministry of Health (R.X., S.L., T.Z., Y.L., T.W., J.Z., Y.S., L.Z., Q.H.).
  • 3. Department of Pathology (Y.L.), Tongji Hospital.
  • 4. Department of Respiratory and Critical Care Medicine (T.W.), Tongji Hospital.
  • 5. Department of Pathology (J.Z.).
  • 6. Department of Respiratory and Critical Care Medicine, Union Hospital (Y.S.).
  • 7. Tongji Medical College, Huazhong University of Science and Technology (HUST), China; Department of Nutrition, Université de Montréal, Canada (M.R.).
  • 8. Montreal Heart Institute, Canada (M.R., J.D.).
  • 9. Department of medicine, Université de Montréal, Canada (J.D.).
  • # Contributed equally.
PMID: 34565182 DOI: 10.1161/HYPERTENSIONAHA.120.16712
Abstract

[Figure: see text].

Keywords
body weight; hypoxia; plasma; polymerization; pulmonary hypertension.
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