Sugar easters and xanthones from the roots of Polygala tenuifolia Willd. and their cytoprotective activity

  • Fitoterapia. 2022 Sep:161:105256. doi: 10.1016/j.fitote.2022.105256.
Bin-Bin Yang  1 ,  Xin-Jie Li  2 ,  Kai Yu  2 ,  Xi-Lan Jiang  1 ,  Lun Wang  1 ,  Fu Li  1 ,  Ming-Kui Wang  3
Affiliations
  • 1. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 2. School of Life Sciences, Southwest Jiaotong University, Chengdu 610031, China.
  • 3. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].
PMID: 35870664 DOI: 10.1016/j.fitote.2022.105256
Abstract

Six new sugar esters (1-6), named tenuifolisides F-G (1-2) and tenuifolioses W-Z (3-6), together with 16 known compounds (7-22) were isolated from the roots of Polygala tenuifolia. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS techniques together with chemical methods. All the compounds were evaluated for the cytoprotective activity against hydrogen peroxide (H2O2)-induced oxidative stress in human keratinocyte HaCaT cells. Compounds 4, 5, 13, 20 and 22 showed strong cytoprotective effect.

Keywords
Cytoprotective activity; HaCaT cells; Polygala tenuifolia; Sugar esters.
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