Cyophiobiolins A-D, ophiobolin sestertepenoids from Cytospora rhizophorae

  • Phytochemistry. 2022 Nov:203:113352. doi: 10.1016/j.phytochem.2022.113352.
Yanjiang Zhang  1 ,  Hongxin Liu  2 ,  Yuchan Chen  2 ,  Xiuxiang Lu  1 ,  Zhaoming Liu  2 ,  Haibo Tan  3 ,  Weimin Zhang  2
Affiliations
  • 1. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 2. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China.
  • 3. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: [email protected].
PMID: 35988743 DOI: 10.1016/j.phytochem.2022.113352
Abstract

Cyophiobiolins A-D, four unreported ophiobolin-type sesterterpenoids, were isolated from Cytospora rhizophorae A761, an endophytic fungus from Gynochthodes officinalis. The structures of these undescribed compounds were fully characterized on the basis of extensively spectroscopic data (1D, 2D NMR and HRESIMS) and single-crystal X-ray diffraction analyses. Moreover, cyophiobiolins A-D were evaluated for in vitro cytotoxic, anti-inflammatory, and Antibacterial activities. Cyophiobiolins A-B showed inhibitory potency against lipopolysaccharide (LPS)-induced oxide production with IC50 values of 66.3 μM and 53.3 μM, respectively.

Keywords
Anti-inflammatory activity; Cyophiobiolins; Cytospora rhizophorae; Endophytic fungus; Gynochthodes officinalis; Rubiaceae; Valsaceae.
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