Copper boosts pro-inflammatory state of macrophages

  • Nat Rev Immunol. 2023 Jun;23(6):344. doi: 10.1038/s41577-023-00889-3.
Alexandra Flemming  1
Affiliations
PMID: 37173540 DOI: 10.1038/s41577-023-00889-3
Abstract

Copper( ii ) ions promote the metabolic and epigenetic remodelling of macrophages towards a pro-inflammatory state. A copper-binding metformin dimer showed promising results in mouse models of inflammation.

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