Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving-Williams Series to completely eradicate Staphylococcus aurous

  • Dalton Trans. 2023 Sep 13;52(35):12203-12207. doi: 10.1039/d3dt01904g.
Khalil Mudarmah  1  2 ,  Bijaya Bagale  1 ,  Guanyu Chen  1 ,  Jeanette A Krause  3 ,  Jeffrey D Mighion  1 ,  Songping D Huang  1
Affiliations
  • 1. Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. [email protected].
  • 2. Department of Chemistry, Jazan University, Jazan, 45142, Saudi Arabia.
  • 3. Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
PMID: 37609944 DOI: 10.1039/d3dt01904g
Abstract

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn(II) ionophore results in the synthesis of Mn(BQ)2(DMSO)2·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL-1). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.

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