Isolation and Characterization of Antimicrobial Metabolites from the Sophora tonkinensis-Associated Fungus Penicillium sp. GDGJ-N37

  • Molecules. 2024 Jan 10;29(2):348. doi: 10.3390/molecules29020348.
Lili Huang  1 ,  Yongxia Li  1 ,  Jing Pang  1 ,  Liuxia Lv  1 ,  Jiatong Zhou  1 ,  Liqi Liang  1 ,  Xianhua He  1 ,  Jun Li  1 ,  Weifeng Xu  1 ,  Ruiyun Yang  1
Affiliations
  • 1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
PMID: 38257261 DOI: 10.3390/molecules29020348
Abstract

Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3-6), together with two new chromone derivatives, penithochromones X and Y (7 and 8). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis. Sclerotioramine (3) showed significant Antibacterial activities against B. subtilis and S. dysentery, and it also showed most potent anti-plant pathogenic fungi activities against P. theae, C. miyabeanus, and E. turcicum.

Keywords
Penicillium sp.; Sophora tonkinensis; antibacterial activities; antifungal activities; azaphilone derivatives.
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