Pleosmaranes A-R, Isopimarane and 20-nor Isopimarane Diterpenoids with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Pleosporales sp. HNQQJ-1

  • J Nat Prod. 2024 Feb 23;87(2):304-314. doi: 10.1021/acs.jnatprod.3c00893.
Guisheng Wang  1  2  3 ,  Yilin Yuan  2 ,  Zhaokun Li  1 ,  Xuguang Liu  2 ,  Yanhai Chu  2 ,  Zhigang She  3 ,  Wenyi Kang  2 ,  Yan Chen  1  2
Affiliations
  • 1. School of Pharmacy, Anhui Medical University, Hefei 230032, China.
  • 2. National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
  • 3. School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
PMID: 38320172 DOI: 10.1021/acs.jnatprod.3c00893
Abstract

Pleosmaranes A-R (1-18), 18 new isopimarane-type Diterpenoids, together with four known analogs (19-22), were isolated from the mangrove endophytic fungus Pleosporales sp. HNQQJ-1. Their structures and absolute configurations were established by analysis of their spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-9 possess an unusual aromatic B ring and a 20-nor-isopimarane skeleton. Compounds 15-17 contain a unique 2-oxabicyclo[2.2.2]octane moiety. Compound 18 features an unexpected 2-oxabicyclo[3.2.1]octane moiety. Compounds 8 and 12 exhibited a moderate inhibitory effect against LPS-induced NO production, with IC50 values of 19 and 25 μM, respectively.