Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

  • J Mater Chem B. 2024 Aug 22;12(33):8062-8066. doi: 10.1039/d4tb00960f.
Yupeng Ren  1 ,  Ling Zeng  2 ,  Yingsen Tang  2 ,  Jing Liao  2 ,  Meng Jiang  2 ,  Xinxiu Cao  1 ,  Hui Fan  1 ,  Jinjin Chen  2
Affiliations
  • 1. Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion, School of Materials Science and Engineering, Hunan University of Science and Technology, 2 Taoyuan Street, Xiangtan 411201, P. R. China. [email protected].
  • 2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. [email protected].
PMID: 39099464 DOI: 10.1039/d4tb00960f
Abstract

The application of mRNA therapy is constrained by the current lipid nanoparticles' (LNPs) inability to target non-liver tissues. In this study, we demonstrate that ionizable lipids equipped with branched and biodegradable tails enhance the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells. This approach offers novel insights into how the chemical structure of LNPs influences their organ-specific targeting capabilities.

Products