Synergistic potential of PD-1 blockade and IL-2 in cancer therapy via targeted bi-functional molecule design

  • Sci Bull (Beijing). 2025 Aug 11:S2095-9273(25)00809-6. doi: 10.1016/j.scib.2025.08.008.
Shengjie Li  1 ,  Siyuan Yu  2 ,  Mengzhao Wang  2 ,  Bo Zhang  3 ,  Yan Xu  4
Affiliations
  • 1. Biomedical Engineering Facility of National Infrastructures for Translational Medicine, Institute of Clinical Medicine and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • 2. Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • 3. State Key Laboratory of Complex Severe and Rare Diseases, Institute of Clinical Medicine and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address: [email protected].
  • 4. Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address: [email protected].
PMID: 40887375 DOI: 10.1016/j.scib.2025.08.008
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