Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss

  • Cell Commun Signal. 2025 Oct 14;23(1):438. doi: 10.1186/s12964-025-02450-2.
Yuelin Zhu  #  1  2 ,  Qianqian Li  #  1  2 ,  Xin Yu  #  1  3 ,  Yun Yang  1  2 ,  Qian Yang  4 ,  Yongqing Wang  5 ,  Xuan Shao  6  7  8 ,  Yan-Ling Wang  9  10  11
Affiliations
  • 1. State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • 2. University of Chinese Academy of Sciences, Beijing, 101408, China.
  • 3. Beijing Institute of Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • 4. NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, 200433, China.
  • 5. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China. [email protected].
  • 6. State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • 7. Beijing Institute of Stem Cell and Regenerative Medicine, Beijing, 100101, China. [email protected].
  • 8. University of Chinese Academy of Sciences, Beijing, 101408, China. [email protected].
  • 9. State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • 10. Beijing Institute of Stem Cell and Regenerative Medicine, Beijing, 100101, China. [email protected].
  • 11. University of Chinese Academy of Sciences, Beijing, 101408, China. [email protected].
  • # Contributed equally.
PMID: 41088442 DOI: 10.1186/s12964-025-02450-2
Keywords
Ferroptosis; GPX4; Lactate; Placental trophoblast; Recurrent pregnancy loss; SCD1.
Products